Cold Recombinant Influenza B/Texas/1/84 Vaccine Virus (CRB 87): Attenuation, Immunogenicity, and Efficacy against Homotypic Challenge
Identifieur interne : 002103 ( Main/Exploration ); précédent : 002102; suivant : 002104Cold Recombinant Influenza B/Texas/1/84 Vaccine Virus (CRB 87): Attenuation, Immunogenicity, and Efficacy against Homotypic Challenge
Auteurs : Wendy A. Keitel [États-Unis] ; Robert B. Couch [États-Unis] ; Thomas R. Cate [États-Unis] ; Howard R. Six [États-Unis] ; Barbara D. Baxter [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1990.
Abstract
Healthy susceptible young adults were inoculated intranasally with increasing doses of wildtype influenza B/Texas/1/84, or the cold-adapted vaccinepossessingthe genesspecifyingthe hemagglutinin and neuraminidase of the wild-type parent and the six internal genes of cold adapted BlAnn Arbor/1/66 (CRB 87). Most volunteers inoculated with 106.6–107.6 TCID50 of CRB 87 were infected, but a high frequency of serum antibody responses was seen only at the highest dose (17/29; 59%). The dose of CRB 87 necessary to infect 50% of all human volunteers (1 HIDso) was ∼105.4 TCID50) All volunteers given 103.9–107.1 TCID50 of the wild-type virus were infected (i.e., 1 HIDso was <103.9 TCID50) . The frequency of mild febrile reactions, mean peak titer of virus in respiratory secretions, and duration of virus shedding were significantly greater in volunteers given 107.1 TCID50 of wild-type virus than in those given 107.6 TCID50 of CRB 87. Thirteen volunteers were rechallenged with a second 107.6 TCID50 dose of CRB 87 3–4 months after vaccination. The frequencies of mild upper respiratory symptoms and signs, virus shedding, and infection were significantly reduced in prior vaccinees compared with volunteers inoculated with a similar dose for the first time. These data suggest that CRB 87 is attenuated, immunogenic, and can confer protection against homotypic virus challenge in this susceptible population.
Url:
DOI: 10.1093/infdis/161.1.22
Affiliations:
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Keitel</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Influenza Research Center and the Departments of Microbiology and Immunology and Medicine, Baylor College of Medicine, Houston</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Reprints and correspondence: Dr. Wendy A. Keitel, The Influenza Research Center, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Couch, Robert B" sort="Couch, Robert B" uniqKey="Couch R" first="Robert B." last="Couch">Robert B. 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Baxter</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Influenza Research Center and the Departments of Microbiology and Immunology and Medicine, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1990-01">1990</date><biblScope unit="vol">161</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="22">22</biblScope><biblScope unit="page" to="26">26</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Healthy susceptible young adults were inoculated intranasally with increasing doses of wildtype influenza B/Texas/1/84, or the cold-adapted vaccinepossessingthe genesspecifyingthe hemagglutinin and neuraminidase of the wild-type parent and the six internal genes of cold adapted BlAnn Arbor/1/66 (CRB 87). Most volunteers inoculated with 106.6–107.6 TCID50 of CRB 87 were infected, but a high frequency of serum antibody responses was seen only at the highest dose (17/29; 59%). The dose of CRB 87 necessary to infect 50% of all human volunteers (1 HIDso) was ∼105.4 TCID50) All volunteers given 103.9–107.1 TCID50 of the wild-type virus were infected (i.e., 1 HIDso was <103.9 TCID50) . The frequency of mild febrile reactions, mean peak titer of virus in respiratory secretions, and duration of virus shedding were significantly greater in volunteers given 107.1 TCID50 of wild-type virus than in those given 107.6 TCID50 of CRB 87. Thirteen volunteers were rechallenged with a second 107.6 TCID50 dose of CRB 87 3–4 months after vaccination. The frequencies of mild upper respiratory symptoms and signs, virus shedding, and infection were significantly reduced in prior vaccinees compared with volunteers inoculated with a similar dose for the first time. These data suggest that CRB 87 is attenuated, immunogenic, and can confer protection against homotypic virus challenge in this susceptible population.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Keitel, Wendy A" sort="Keitel, Wendy A" uniqKey="Keitel W" first="Wendy A." last="Keitel">Wendy A. Keitel</name></region><name sortKey="Baxter, Barbara D" sort="Baxter, Barbara D" uniqKey="Baxter B" first="Barbara D." last="Baxter">Barbara D. Baxter</name><name sortKey="Cate, Thomas R" sort="Cate, Thomas R" uniqKey="Cate T" first="Thomas R." last="Cate">Thomas R. Cate</name><name sortKey="Couch, Robert B" sort="Couch, Robert B" uniqKey="Couch R" first="Robert B." last="Couch">Robert B. Couch</name><name sortKey="Keitel, Wendy A" sort="Keitel, Wendy A" uniqKey="Keitel W" first="Wendy A." last="Keitel">Wendy A. Keitel</name><name sortKey="Six, Howard R" sort="Six, Howard R" uniqKey="Six H" first="Howard R." last="Six">Howard R. Six</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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